Mapping nutrient uptake and processing in Mycobacterium tuberculosis

Lead Research Organisation: University of Warwick
Department Name: School of Life Sciences

Abstract

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) and is a global killer, in 2015 it infected an estimated 10.4 million people and killed an estimated 1.8 million people. New drugs and therapeutic strategies are urgently required to combat the global increase in drug-resistant strains of Mtb.
Mtb has evolved strategies to evade the host immune system and is able to survive within the macrophage environments for decades without causing disease. However, the nutrients that Mtb uses and metabolises are poorly understood. In this project, we will utilise an exciting multi-disciplinary approach to determine the biosynthetic pathways involved in nutrient uptake and metabolism in the Mtb pathogen. These studies will provide new insights into the molecular basis of nutrient recognition and biochemical pathways involved in the Mtb pathogen and have a direct impact on the development of new strategies to combat this global disease.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
1786898 Studentship BB/M01116X/1 03/10/2016 31/01/2021 Hadyn Luke Parker
 
Description General Travel Grant Mycobacterial heterogeneity and host tissue tropism symposium 2020, New Delhi, India
Amount £390 (GBP)
Organisation Biochemical Society 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2020 
End 02/2020
 
Description Travel Grant Mycobacterial heterogeneity and host tissue tropism symposium 2020, New Delhi, India
Amount £390 (GBP)
Funding ID GA001829 
Organisation Microbiology Society 
Sector Learned Society
Country United Kingdom
Start 02/2020 
End 02/2020
 
Description Medical and Life Sciences Research Fund Reception 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact On 10th December 2019 I presented an overview of the current state of Mycobacterium tuberculosis research with a focus on antimicrobial resistance and drug discovery at Warwick Medical School. This reception was open to members of the Medical and Life Sciences Research Fund and donors from the Clifford Chambers and surrounding areas of Warwickshire.
Year(s) Of Engagement Activity 2019
 
Description University open day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact On 22nd & 23rd June, 6th October, 20th October 2018, 21st & 22nd June and 5th October 2019 I spoke to prospective students and their parents/guardians, throughout the day, on the global impact of Mycobacterium tuberculosis, raising its profile and challenging public assumptions about the disease. I also explained the research we are conducting at Warwick to help fight M. tuberculosis.
Year(s) Of Engagement Activity 2018,2019,2020
 
Description World TB Day 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The laboratory held an information/demonstration stand for World TB Day. This event was held at the Coventry central library. This led to lots of interesting discussions around TB, the research that we are doing and what we need to do to eradicate this pathogen.
Year(s) Of Engagement Activity 2019