Taste-masked nanofibres for paediatric drug delivery

Lead Research Organisation: University College London
Department Name: School of Pharmacy

Abstract

The effective delivery of medications to children remains a major challenge, not only because of the distinct distribution profiles associated with this population but also due to issues of acceptability and palatability that are closely associated with concordance. The problem becomes exacerbated within the global perspective, with particular issues inclduing cost and practicality of administration. Our hypothesis is that rapidly disintegrating dosage forms (which 'melt' in the mouth) may be designed so as to simultaneously mask drug taste via nanofiber incorporation. We believe that such a system is now feasible from an efficacy and
manufacturing perspective, as low-cost nanofibers provide a novel means of simultaneously controlling release, taste and mouthfeel. Here we use recent technology to produce nanofibers on a realistic scale which may be incorporated into films disintegrating in the mouth. We will also use our suite of taste assessment facilities to measure masking efficacy.

Main Methods and Techniques to be employed:
- Nanofibre production using pressurized gyration, in collaboration with Colleagues in the Department of Mechanical Engineering.
- Formulation of nanofibres into orally disintegrating dosage forms.
- Assessment of taste using a range of systems ranging from electronic biosensor systems to human taste panels

Publications

10 25 50
 
Description Pfizer
Amount £38,800 (GBP)
Organisation Pfizer Ltd 
Sector Private
Country United Kingdom
Start 10/2016 
End 10/2020
 
Description AAPS - San Diego 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Attended and presented a poster at the AAPS conference in November 2017, held in San Diego, CA, USA.
Year(s) Of Engagement Activity 2017
 
Description EuPFI - Warsaw 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Attended the 9th European conference on Paediatric Formulation Initiative, held in Warsaw, Poland in 2017. I presented a poster of my work and networked with professionals from the MHRA. From attending other talks I gained ideas for my own research.
Year(s) Of Engagement Activity 2017
 
Description PBP - Granada, 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Attended and presented a poster at the PBP World meeting, March 2018, held in Granada, Spain.
Year(s) Of Engagement Activity 2018
 
Description SPaeDD-UK Accelerating paediatric formulation development - London, 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact SPaeDD event was held in London, March 2018. Attended talks and presented a poster.
Year(s) Of Engagement Activity 2018
 
Description The UK-China mini symposium on electrospinning in drug delivery - London, 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Attended and presented a poster at the UK-China mini symposium on electrospinning in drug delivery.
Year(s) Of Engagement Activity 2018
 
Description UCL PhD Research Day - London, 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact An event held locally at UCL School of Pharmacy - attended relevant talks and presented a 3 min talk on research, alongside presenting a poster. Held in London in September 2018.
Year(s) Of Engagement Activity 2018
 
Description ULLA Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Attended the ULLA Summer School in summer of 2017, held in Leuven, Belgium. As part of the week long programme, I presented a posted of my research.
Year(s) Of Engagement Activity 2017