Taste-masked nanofibres for paediatric drug delivery
Lead Research Organisation:
University College London
Department Name: School of Pharmacy
Abstract
The effective delivery of medications to children remains a major challenge, not only because of the distinct distribution profiles associated with this population but also due to issues of acceptability and palatability that are closely associated with concordance. The problem becomes exacerbated within the global perspective, with particular issues inclduing cost and practicality of administration. Our hypothesis is that rapidly disintegrating dosage forms (which 'melt' in the mouth) may be designed so as to simultaneously mask drug taste via nanofiber incorporation. We believe that such a system is now feasible from an efficacy and
manufacturing perspective, as low-cost nanofibers provide a novel means of simultaneously controlling release, taste and mouthfeel. Here we use recent technology to produce nanofibers on a realistic scale which may be incorporated into films disintegrating in the mouth. We will also use our suite of taste assessment facilities to measure masking efficacy.
Main Methods and Techniques to be employed:
- Nanofibre production using pressurized gyration, in collaboration with Colleagues in the Department of Mechanical Engineering.
- Formulation of nanofibres into orally disintegrating dosage forms.
- Assessment of taste using a range of systems ranging from electronic biosensor systems to human taste panels
manufacturing perspective, as low-cost nanofibers provide a novel means of simultaneously controlling release, taste and mouthfeel. Here we use recent technology to produce nanofibers on a realistic scale which may be incorporated into films disintegrating in the mouth. We will also use our suite of taste assessment facilities to measure masking efficacy.
Main Methods and Techniques to be employed:
- Nanofibre production using pressurized gyration, in collaboration with Colleagues in the Department of Mechanical Engineering.
- Formulation of nanofibres into orally disintegrating dosage forms.
- Assessment of taste using a range of systems ranging from electronic biosensor systems to human taste panels
People |
ORCID iD |
Duncan Craig (Primary Supervisor) |
Publications
Abdelhakim H
(2021)
Utilising Co-Axial Electrospinning as a Taste-Masking Technology for Paediatric Drug Delivery
in Pharmaceutics
Abdelhakim HE
(2020)
Human mouthfeel panel investigating the acceptability of electrospun and solvent cast orodispersible films.
in International journal of pharmaceutics
Abdelhakim HE
(2019)
Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a Design of Experiment Approach.
in Molecular pharmaceutics
Ekweremadu CS
(2020)
Development and Evaluation of Feline Tailored Amlodipine Besylate Mini-Tablets Using L-lysine as a Candidate Flavouring Agent.
in Pharmaceutics
Li J
(2022)
Drug Delivery Applications of Coaxial Electrospun Nanofibres in Cancer Therapy.
in Molecules (Basel, Switzerland)
Tawfik EA
(2021)
A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets.
in Pharmaceutics
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/N018451/1 | 30/09/2016 | 29/03/2021 | |||
1789601 | Studentship | MR/N018451/1 | 30/09/2016 | 29/03/2021 |
Description | Pfizer |
Amount | £38,800 (GBP) |
Organisation | Pfizer Ltd |
Sector | Private |
Country | United Kingdom |
Start | 09/2016 |
End | 10/2020 |
Description | AAPS - San Diego 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Attended and presented a poster at the AAPS conference in November 2017, held in San Diego, CA, USA. |
Year(s) Of Engagement Activity | 2017 |
Description | EuPFI - Warsaw 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Attended the 9th European conference on Paediatric Formulation Initiative, held in Warsaw, Poland in 2017. I presented a poster of my work and networked with professionals from the MHRA. From attending other talks I gained ideas for my own research. |
Year(s) Of Engagement Activity | 2017 |
Description | Oral presentation at Bologna PBP conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Utilising co-axial electrospinning as a taste-masking technology for paediatric drug delivery oral presentation at Bologna PBP conference |
Year(s) Of Engagement Activity | 2019 |
Description | Oral presentation at UK-China mini symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Utilising co-axial electrospinning as a taste-masking technology for paediatric drug delivery oral presentation in London |
Year(s) Of Engagement Activity | 2019 |
Description | PBP - Granada, 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Attended and presented a poster at the PBP World meeting, March 2018, held in Granada, Spain. |
Year(s) Of Engagement Activity | 2018 |
Description | Poster presentation at APS conference in Greenwich |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Poster presentation in London |
Year(s) Of Engagement Activity | 2019 |
Description | SPaeDD-UK Accelerating paediatric formulation development - London, 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | SPaeDD event was held in London, March 2018. Attended talks and presented a poster. |
Year(s) Of Engagement Activity | 2018 |
Description | The UK-China mini symposium on electrospinning in drug delivery - London, 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Attended and presented a poster at the UK-China mini symposium on electrospinning in drug delivery. |
Year(s) Of Engagement Activity | 2018 |
Description | UCL PhD Research Day - London, 2018 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | An event held locally at UCL School of Pharmacy - attended relevant talks and presented a 3 min talk on research, alongside presenting a poster. Held in London in September 2018. |
Year(s) Of Engagement Activity | 2018 |
Description | ULLA Summer School |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Attended the ULLA Summer School in summer of 2017, held in Leuven, Belgium. As part of the week long programme, I presented a posted of my research. |
Year(s) Of Engagement Activity | 2017 |