Activity-directed synthesis toolkit

Lead Research Organisation: University of Leeds
Department Name: Sch of Chemistry

Abstract

Activity-directed synthesis (ADS) is a novel discovery approach in which bioactive small molecules emerge in parallel with an associated synthetic route. This iCASE project (in collaboration with GSK) will focus on expansion of the reaction toolkit for ADS to enable scaffold hopping. The new chemical tools will be exploited in the ADS of small molecule modulators of exemplar protein targets.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/P510555/1 01/10/2016 30/09/2021
1799580 Studentship EP/P510555/1 01/10/2016 30/09/2020 Adam Ieuan Green
 
Description Activity-directed synthesis toolkit
Amount £90,584 (GBP)
Funding ID 1799580 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2020