Control of alternative pre-mRNA splicing in the generation of inflammation and pain

Lead Research Organisation: University of Nottingham
Department Name: School of Life Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Beazley-Long N (2018) The physiological functions of central nervous system pericytes and a potential role in pain. in F1000Research

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Durrant AM (2018) A role for pericytes in chronic pain? in Current opinion in supportive and palliative care

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M008770/1 30/09/2015 31/03/2024
1804143 Studentship BB/M008770/1 30/09/2016 29/09/2020
 
Description We have demonstrated that a novel class of drugs have the ability to reverse chemotherapy induced sensitisation of sensory neurons in vitro. We have also demonstrated that these novel drugs are provide a degree of neuroprotection to neurons treated with chemotherapy.
Exploitation Route Further confirmation of novel drug potential via in vivo experiments and if successful, eventual application in various clinical trials to prove drug efficacy.
Sectors Healthcare

Pharmaceuticals and Medical Biotechnology
 
Description Visit to Former Undergraduate Course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Attended a careers day for my undergraduate degree to talk about how to get access to a PhD programme and what day to day life entails as a PhD student. Answered student questions and delivered a short presentation to ~40 undergrad students. Received feedback that a couple of students would seek to pursue a PhD in the future.
Year(s) Of Engagement Activity 2016,2019,2020