Angiogenesis & Remodelling post Myocardial Infarction
Lead Research Organisation:
University of Glasgow
Department Name: School of Mathematics & Statistics
Abstract
The aim of this research project to develop a new a mathematical and computational model of the coronary arterial and veno us circulation in the beating heart to include changes that are manifest once circulation has been restored after a heart attack, and to predict the consequent angiogenesis. We will develop a new circulation model for pulsatile flow and pressure that incorporates structured-trees that represent the small coronary arterial and venous vascular beds, in order to quantify the effects of the external pressures on the small vessels due to the contraction of the wall of the beating heart. Wave intensity analysis w ill be used to identify differences in reflected waves post-MI and the model will be validated with laboratory measurements
The flows in the vascular beds, together with data on the stresses and strains from full fluid-structure simulations of the left ventricle, will be used to extend our individual- and force-based model of tiss ue in the myocardium to predict angiogenesis in and around the infarct, accounting for cell-cell, cell-fibre and cell-ECM interactions.
The flows in the vascular beds, together with data on the stresses and strains from full fluid-structure simulations of the left ventricle, will be used to extend our individual- and force-based model of tiss ue in the myocardium to predict angiogenesis in and around the infarct, accounting for cell-cell, cell-fibre and cell-ECM interactions.
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509668/1 | 01/10/2016 | 30/09/2021 | |||
| 1805091 | Studentship | EP/N509668/1 | 01/10/2016 | 18/06/2020 | Jay Mackenzie |
| Description | We have developed a new boundary condition that allows us to match up arterial and venous circulations, including the flow and fluid pressure at the boundary. This is done using a structured tree which is essentially an average description of a vascular bed. This boundary condition includes the effects of exerting external pressure upon a vascular bed. |
| Exploitation Route | Our associated computational model can be used to study how disease mechanisms impact observable physiological results, such as the link between peripheral vessel stiffening and high arterial blood pressure. |
| Sectors | Healthcare |
| Description | 7 minutes of science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | 7 minutes of science is a public engagement event organized by the Physics & Astronomy Society at the University of Glasgow. As the name implies, researchers have 7 minutes to present their research to a general, but science savvy, audience; in this time I explain what I'm trying to model, why it's important, and how I model it. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Explorathon 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We had a table in a local museum during the European Researcher's night 2018 with toys and props for people to play with. As they played we explained the significance of what they were playing with to our research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Explorathon 2018 Schools Visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | I, along with two other researchers, visited a local primary school with props that illustrated some key features of our research. We encouraged the children to wonder about the mechanisms behind the observations they were making, i.e. why is a corn flour/water mixture non-Newtonian and why does this matter when modelling, e.g. blood flow. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Science slam 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The science slam is competitive public engagement. Eight researchers each have 10 minutes to explain what they research and why it's important and interesting. I did this in 2017. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.youtube.com/watch?v=gO8SJSSI6RI |