Novel microchip-based diagnostic tools for metabolite detection.

Lead Research Organisation: University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci

Abstract

Studentship strategic priority area: Sensors and instrumentation

Abstract: Tools enabling the diagnosis of disease that also assist in tailoring drug therapies most suitable for individual patients are emerging. Among the key breakthroughs has been the discovery that changes in levels of various biochemicals can point to disease. This has been long known in conditions such as diabetes where uncontrolled glucose levels are the primary marker used in diagnosis. As we learn more about metabolism, so other biochemical markers of disease have emerged. It is possible to determine levels of metabolites based on the ability of specific enzymes to convert them to products that can be detected using microchips. In this project we propose to use enzymes to identify multiple different metabolite-markers associated with disease using a chip based format. The project will focus on developing enzyme assays, coupled to microchip surfaces linked to sensor arrays to quantify metabolites whose perturbation is known to be associated with cardiovascular disease.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509668/1 30/09/2016 29/09/2021
1818380 Studentship EP/N509668/1 02/10/2016 02/04/2020 Andreea Stroia