Investigating molecular mechanisms of Clostridium difficile colonisation

Lead Research Organisation: University of Warwick
Department Name: School of Life Sciences

Abstract

Clostridium difficile remains aetiological agent for antibiotic-associated diarrhoea (AAD) within the UK, with 13,268 reported cases of C. difficile Infection (CDI) between April 2017 and March 2018. The majority of reported cases result from nosocomial infections; however, the proportion of community-acquired infection is on the rise. Animals of agricultural importance such as bovine and swine are hypothesised to act as reservoirs for a few ribotypes capable of inter-species transmission. Also, C. difficile is a leading cause of diarrhoea in piglets in many parts of the world. The mechanisms and interaction involved in the colonisation of the gastrointestinal tract is still poorly understood, thus this project aims to define genes important for the early stages of infection using sequencing-based technologies. Identification and functional analysis of proteins critical to C. difficile colonisation will enhance our understanding of C. difficile pathogenesis and lead to effective interventions for CDI.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
1897785 Studentship BB/M01116X/1 02/10/2017 30/09/2021 Jeffrey Cheng
 
Description Public Science Evening: Bad Cell Service 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact On the 1st May, the QBP hosted a public science evening to explore the idea of 'Bad Cell Service', and what happens when cells misbehave. There were talks from PhD students, postdoctoral researchers, and professors, each giving a unique insight into cellular biology. We also included a range of tours that allowed our guests to get a behind the scenes look at the exciting research that takes place, and the facilities that we have here.
Year(s) Of Engagement Activity 2019
URL https://warwick.ac.uk/fac/sci/med/qbp/public/pastevents/
 
Description University of Warwick Science on the Hill 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Approximately 50-70 people attended an evening where researchers and students alike communicate their research. The evening aims to highlight current global crises that occur within the biological world and how our research aims to combat this. The audience members were primarily composed of teenagers, embarking onto either GCSE, A levels or a higher level education and senior members. We have hoped to influenced the publics views on the growing crisis of AMR and other bacteriological problems that exist.
Year(s) Of Engagement Activity 2019
URL https://warwick.ac.uk/about/publicengagement/events/scienceonthehill/