Structural and Functional Studies of Cannabidiol Interactions With Voltage-gated Sodium Channels
Lead Research Organisation:
Birkbeck, University of London
Department Name: Biological Sciences
Abstract
Using structural and biophysical methods to explore the interactions between cannabidiol and voltage-gated sodium ion channels, using the prokaryotic sodium ion channel NavMs as a model.
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013867/1 | 01/10/2016 | 30/09/2025 | |||
| 1905211 | Studentship | MR/N013867/1 | 01/10/2017 | 30/09/2021 | Lily Goodyer Sait |
| Title | Crystallographic Coordinates of 6Yz2 |
| Description | crystal structure coordinated deposited in the pdb |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Crystallographic coordiantes used by other researchers |
| Title | PDB 6YZ0 |
| Description | Crystallographic coordinates deposited in the Protein Data Bank |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Used by structural Biologists |
| Description | Collaboration with Simon Fraser University, Canada |
| Organisation | Simon Fraser University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | The Wallace team (Birkbeck) did all the structural and bioinformatics aspects of the partnership |
| Collaborator Contribution | Prof P. Ruben's lab did the electrophysilogy aspects of the partnership, leading to a joint publication |
| Impact | Publication (2020) in Elife which was also reported in an article written by the Diamond Light Source (and on their website). |
| Start Year | 2020 |
| Description | GW Pharmaceuticals collaboration |
| Organisation | GW Pharmaceuticals |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Carrying out research into the interaction between CBD and VGSCs. GW deals in CBD, thus it is important that its interactions are understood. |
| Collaborator Contribution | They provided CBD for the experiments. |
| Impact | On-going experiments and investigations into the structural interaction between CBD and VGSCs. |
| Start Year | 2019 |