How do gut bacteria strains boost our immune system? (JUGE_Q17DTPR)
Lead Research Organisation:
University of East Anglia
Department Name: Graduate Office
Abstract
Gut bacteria are major players of human health and disease. Numerous studies have shown correlations between the gut microbiota composition and an ever-growing list of human diseases. However, the molecular mechanisms underpinning the interaction of gut commensal bacteria with the host remain ill-defined, limiting meaningful interventions to restore microbial balance.
The objectives of the proposed PhD studentship project are to determine the impact of bacterial adhesins on the host immune response of Lactobacillus reuteri strains in the mammalian gastrointestinal tract. It is expected that the results from this PhD project will pinpoint molecular determinants important for retention and immunomodulatory properties of L. reuteri in the gut. This knowledge is key to the design and/or selection of probiotic strains with the required specificities.
The objectives of the proposed PhD studentship project are to determine the impact of bacterial adhesins on the host immune response of Lactobacillus reuteri strains in the mammalian gastrointestinal tract. It is expected that the results from this PhD project will pinpoint molecular determinants important for retention and immunomodulatory properties of L. reuteri in the gut. This knowledge is key to the design and/or selection of probiotic strains with the required specificities.
Organisations
People |
ORCID iD |
| Nathalie Juge (Primary Supervisor) | |
| Yemane Tedros (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011216/1 | 01/10/2015 | 31/03/2024 | |||
| 1937649 | Studentship | BB/M011216/1 | 01/10/2017 | 30/09/2021 | Yemane Tedros |
| Description | 30th Joint Glycobiology Meeting - Lille, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Joint Glycobiology Meeting (JGM) brought together European laboratories with major interest in Glycobiology which is considered as an emerging field impacting many biological aspects especially human physiology, development and diseases. The objectives of this meeting were to foster young scientists (PhD and Post-Doc students), early in their career, and to give them the opportunity to present and share their results to a high profile scientific audience. JGM is organized annually by "Studiengruppe Glykobiologie der GBM", the "Netherlands Society for Glycobiology", the "Groupe Lillois de Glycobiologie", and the "Belgian Working Group for Glycosciences" and occurs each year in one of these contries : Belgium, France, Germany or The Netherlands. |
| Year(s) Of Engagement Activity | 2019 |
| Description | GlycoBioTec2019 - Berlin, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The conference was an interactive forum for discussing cutting-edge research on the frontiers of Glycobiotechnology, spanning fundamental theory to method & technology developments relevant to Biopharma, health, medicine and functional food areas. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Introductory Workshop on Biomedical Glycoscience - San Sebastian, Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | This workshop was organised by the Spanish Network of Excellence in Chemical Glycobiology. Glycobiochem also provided scholarly seminars from leading experts on glycosylation and cancer, immune therapy, glycoconjugate vaccine design and antimicrobial resistance and technologies important for analyzing glycan structure and carbohydrate-protein interactions. At the same time the 2,5 day workshop provided a forum for participants to present their own research via poster and oral presentations and foster new collaborations with international colleagues. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Knowledge Exchange Programme 2019 - Freising Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Knowledge Exchange Programme with PhD students from the Quadram Institute, the ZIEL Institute for Food and Health (TUM) and the Fraunhofer Institute for Food Process, Engineering and Packaging. This programme is organised by QSF to interact with PhD Students about ongoing research across the institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Knowledge exchange trip to Parma |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 10 PhD students went on the annual QIB Knowledge Exchange Trip to Parma. The excursion included a visit to two of the institutes in the University of Parma -, as well as an introduction to the work of fruit breeders Fresh Forward, and a tour of Wageningen University Research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Microbes in Norwich Biannual Meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | The Biennial Conference Microbes in Norwich 2019 showcased the breadth and depth of research in Microbiology across the Norwich Research Park. Speakers included Nick le Brun (UEA), Nick Talbot (TSL), Alison Mather (QIB), Laura Lehtovirta-Morley (UEA), Marcelo Batista (JIC), Fred Warren (QIB), Richard Leggett (EI), Gemma Langridge (QIB), David Lea-Smith (UEA), Naiara Beraza (QIB). Plenary Speaker for 2019 was Nicole Dubilier, Director of the Max Plank Institute for Marine Microbiology, Bremen, Germany. There also was a dedicated poster sessions for Early Career Researchers to present their work, and several prizes for the best posters. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Student Science Showcase 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | This was a half-day mini conference where all students at the Quadram Institute got to present their work. It started off with a guest lecture by Dr Josh Quick from University of Birmingham, followed by 8 talks by students in their 3rd or 4th years. All students presented a poster on their work and their will be prizes at the end of the day for the best talks and posters. This was guaranteed to be a really interesting and engaging day, and we welcome you all to attend. Programmes will be sent out closer to the date. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Summer Course Glycosciences 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This broad course in glycosciences combined general introductions in the field of carbohydrates and glycoproteins with in-depth parallel sessions. This gave participants the opportunity to focus on specific interests without losing a broad education. The course was at graduate level. The course is a must for those working in academia, research institutes or industry that want to refresh their knowledge on carbohydrates and for graduate students working on a PhD project related to carbohydrate chemistry, biochemistry, biology, chemical technology or food science. All participants were encouraged to bring a poster in which we introduce themselves and their work. |
| Year(s) Of Engagement Activity | 2018 |