Controlled polymer architectures for the delivery of polynucleotides

Lead Research Organisation: University of Warwick
Department Name: Chemistry

Abstract

The project focuses on the design of polyelectrolytes of controlled architectures to complex a variety of polynucleotides and control their delivery into cells, with a particular focus on the treatment of cancer. A range of polymeric architectures will be studied including linear and branched copolymers, which will be functionalised to target delivery and also carry probe molecules allowing tagging of the delivery vectors for in situ imaging.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509796/1 01/10/2016 30/09/2021
1938888 Studentship EP/N509796/1 02/10/2017 30/09/2021 THOMAS FLOYD
 
Description We have achieved greater understanding of the way the materials are formed through collaborations with a mass spectrometry group at the university.
In addition the way that the polymers interact with nucleic acid and the effect of the polymer structure is becoming more apparent. As well as how these polymers interact with cells in the body.
Exploitation Route This work will hopefully give greater insight into how the architecture of a polymer plays a role in the ability to transfect DNA. Whilst the materials we make might not be useful for translation to the clinic, it might help in the design of newer materials to replace the exisiting ones. This funadmental understanding may aide in the move away from commonly used materials that have unwanted side effects.
Sectors Chemicals,Healthcare

 
Description Towards determination of poly(2-oxazoline) hydrolysis by mass spectrometry 
Organisation University of Warwick
Country United Kingdom 
Sector Academic/University 
PI Contribution Synthesis of materials and discussion of experiments and results
Collaborator Contribution Analysis of materials via mass spectrometry
Impact Understanding of the mechanism of hydrolysis for poly(2-oxazoline)s This is fundamental for my main research project as understanding the hydrolysis allows for the material synthesis to be tuned
Start Year 2019