Synthesis of core-shell nanoparticles in microreactors
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
Nanoparticles (NPs) have attracted the scientific interest during the last decades, currently being used and explored for a large number of application. Lying at the edge between bulk solids and molecular structures, nanoparticles exhibit exceptional properties due to their very small size (1-100 nm) such as extremely high surface energy, high area to volume ratio and quantum confinement effects. Such unique chemical and physical properties makes them interesting in a wide range of fields, including catalysis, biomedical imaging and light emitting technologies.
Despite their potential, their deployment in large scale application require the overcome of a number of hurdles. Their high surface energy means that they are particularly reactive and sensitive to agglomeration. Furthermore, most nanoparticle syntheses are currently carried out using batch procedures on small scales and the scale up of the reactions is often challenging, limiting potential industrial applications.
In order to tackle those issues, this project aims at developing new manufacturing technologies for the synthesis of core/shell nanoparticle, where the outer shell acts as a barrier protecting the inner core composed of the desired material. For this, flow synthesis in microreactor will be explored to maximise their high heat and mass transfer coefficients as well as laminar flow regime, thereby opening up the way to a large scale industrial production.
Despite their potential, their deployment in large scale application require the overcome of a number of hurdles. Their high surface energy means that they are particularly reactive and sensitive to agglomeration. Furthermore, most nanoparticle syntheses are currently carried out using batch procedures on small scales and the scale up of the reactions is often challenging, limiting potential industrial applications.
In order to tackle those issues, this project aims at developing new manufacturing technologies for the synthesis of core/shell nanoparticle, where the outer shell acts as a barrier protecting the inner core composed of the desired material. For this, flow synthesis in microreactor will be explored to maximise their high heat and mass transfer coefficients as well as laminar flow regime, thereby opening up the way to a large scale industrial production.
Organisations
People |
ORCID iD |
Laura Torrente Murciano (Primary Supervisor) | |
Julien Mahin (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/N509620/1 | 01/10/2016 | 30/09/2022 | |||
1945714 | Studentship | EP/N509620/1 | 01/04/2017 | 31/03/2021 | Julien Mahin |
EP/R513180/1 | 01/10/2018 | 30/09/2023 | |||
1945714 | Studentship | EP/R513180/1 | 01/04/2017 | 31/03/2021 | Julien Mahin |
Description | A new method to synthesise iron nanoparticles was developed using microreactor technology. Such nanoparticles have a variety of possible applications, particularly in biotechnology because of their magnetic properties, so they can be used for novel cancer therapies such as magnetic hyperthermia, MRI contrast agents or targeted drug delivery. However, deployment of these nanoparticles has been limited by the difficulties in scaling the manufacturing processes. This work demonstrated a continuous synthesis approach, which unlike traditional batch methods enables high throughput synthesis while maintaining an excellent control over the final nanoparticle properties. It is the first time a continuous synthesis was achieved for metallic iron nanoparticles, which are significantly more magnetic than their oxide counterpart but require environmental stabilization. The reactive iron core was stabilized by an iron oxide passivation shell. Excellent mixing in the reactor was achieved by the gas generated in situ leading to two-phase gas-liquid flow. Overall, the establish process enables large quantities of such nanomaterials to be manufactured reproducibly, with high production rates of several grams per hour. |
Exploitation Route | The general method developed here for iron nanoparticles could be easily applied to other transition metals and the key insights discovered about the fluid dynamics inside the reactors are relevant to other gas-liquid systems, The particles produced in this work could be investigated for relevant applications such as magnetic hyperthermia cancer treatment, |
Sectors | Chemicals,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |