d-Amino Acids and d-Foldamers : New helical constructs for catalysis
Lead Research Organisation:
King's College London
Department Name: Chemistry
Abstract
The synthesis of 3 main delta-amino acid target molecules, and their related analogous, leading to the generation of a library of diverse monomers. From this, simple a,d- peptide sequences will then be synthesised, with a view to eventually synthesising rationally designed, novel aldolase peptide sequences.
A variety of conventional organic synthetic techniques are to be used in the synthesis of the amino acid target molecules, with organocatalysis being a common theme.
Solution phase synthesis used in order to synthesis the desired peptide sequences.
Use of NMR, CD and X-ray crystallography to gain structural information for the peptides.
A variety of conventional organic synthetic techniques are to be used in the synthesis of the amino acid target molecules, with organocatalysis being a common theme.
Solution phase synthesis used in order to synthesis the desired peptide sequences.
Use of NMR, CD and X-ray crystallography to gain structural information for the peptides.
Organisations
People |
ORCID iD |
| Alexander Cobb (Primary Supervisor) | |
| Ryan Stendall (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509498/1 | 01/10/2016 | 30/09/2021 | |||
| 1951102 | Studentship | EP/N509498/1 | 01/10/2017 | 15/06/2022 | Ryan Stendall |
| EP/R513064/1 | 01/10/2018 | 30/09/2023 | |||
| 1951102 | Studentship | EP/R513064/1 | 01/10/2017 | 15/06/2022 | Ryan Stendall |
| Description | The synthesis of novel amino acids and their incorporation into small peptides, diversifying the pool of monomers that could be used to create new enzyme-mimicking structures. |
| Exploitation Route | Using these novel amino acid building blocks, new catalysts and enzyme-like molecules could be created, allowing for the more efficient and versatile synthesis of small molecules in industry (pharma, specialist chemicals, etc). Potential for medicinal applications, ie. antibacterial peptides. |
| Sectors | Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |