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Genetic risk factors involved in brain circuit changes caused by early life adversity

Lead Research Organisation: University of Bristol
Department Name: Physiology and Pharmacology

Abstract

Stressful experiences caused by early life adversity are highly significant in determining a child's future susceptibility to a range of psychiatric disorders including anxiety and depression. This project aims to investigate genetic factors that may influence this susceptibility and the brain circuits perturbed by these events.

People

ORCID iD

Publications

10 25 50
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Griesius S (2020) Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour. in Psychopharmacology

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Griesius S (2022) Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/N013794/1 30/09/2016 29/09/2025
1952898 Studentship MR/N013794/1 30/09/2017 29/09/2021
 
Description Genetic models of psychiatric disorders 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Electrophysiological and behavioural analyses of genetically modified animals
Collaborator Contribution Genetics expertise and animal models. Complementary behavioural analyses.
Impact no outputs as yet. Multidisciplinary collaboration including genetics, rodent behaviour, electrophysiology, imaging
Start Year 2018
 
Description Press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Press releases about our published research (Neuron 2010 and J Neurosci 2011, Nature Neurosci 2012, Cerebral Cortex 2016 and Nature Communications 2016) led to interest from a number of media outlets.

Article on our reserach published in New Scientist.
Year(s) Of Engagement Activity 2010,2011,2013,2015,2016,2017,2018,2019,2020,2021