GPCR drug discovery using the Zebrafish model.
Lead Research Organisation:
University of Sheffield
Department Name: Biomedical Science
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Tanya Whitfield (Primary Supervisor) |
Publications
Diamantopoulou E
(2019)
Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant
in eLife
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011151/1 | 30/09/2015 | 29/09/2023 | |||
| 1961673 | Studentship | BB/M011151/1 | 30/09/2017 | 29/09/2021 | |
| BB/R50581X/1 | 30/09/2017 | 29/09/2021 | |||
| 1961673 | Studentship | BB/R50581X/1 | 30/09/2017 | 29/09/2021 |
| Description | We have uncovered novel compounds that can alleviate inner ear and myelination defects associated with zebrafish adgrg6 mutant larvae. Moreover, we have analysed the structures of such compounds to identify key properties shared between them which in turn have helped us identify additional compounds that induce similar rescuing effects. Finally, we have been able to build evidence surrounding the cellular targets of each compound based on their effects on multiple adgrg6 allelic mutants. Research article in eLIFE: Diamantopoulou et al., 2019 Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant |
| Exploitation Route | Compounds from our work will provide useful new tools for the developmental biologist, and may have potential as lead compounds for the design of new therapeutic drugs to target myelination defects. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| URL | https://elifesciences.org/articles/44889#fig1s1 |
| Description | Sosei Heptares industry collaboration on PhD project |
| Organisation | Heptares Therapeutics Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | I have completed a three month placement at Sosei Heptares during which I continued my PhD project research in the industry setting. The findings throughout my project are shared with Sosei Heptares. |
| Collaborator Contribution | Sosei Heptares have provided funding towards my PhD project and have shared lab equipment and consumables for experimental work. |
| Impact | None as of yet but a Thesis and manuscript will be in the pipeline later this year. |
| Start Year | 2017 |