Dissecting heterogeneity in human pluripotent stem cell-derived dopaminergic neuronal grafts.

Lead Research Organisation: University of Edinburgh
Department Name: MRC Centre for Regenerative Medicine

Abstract

Dissecting heterogeneity in human pluripotent stem cell-derived dopaminergic neuronal grafts.

Publications

10 25 50
 
Description MRC Flexible Supplement funds
Amount £3,780 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 11/2019
 
Description UCB NPIF Funding
Amount £5,000 (GBP)
Organisation UCB Pharma 
Sector Private
Country United Kingdom
Start 06/2019 
End 09/2021
 
Description UCB research partnership 
Organisation UCB Pharma
Department Cellular Sciences - UCB Pharma
Country United Kingdom 
Sector Private 
PI Contribution My project is the second project in the lab which UCB has part funded. We have developed an in-vitro cell model of Parkinson's disease which is being utilised to explore potential treatments, as well as identifying potential biomarkers of the condition. The later aim is the main focus of my PhD and I am currently working towards this goal, to date optimising a super-resolution technique for examining pathological protein oligomers in conditioned medium.
Collaborator Contribution UCB have provided funding and pre-formed alpha synuclein fibrils which are used to induce alpha synuclein pathology within our cell model of Parkinson's disease. They have also provided advice and guidance, and have agreed to set up bimonthly meetings to monitors it's progress.
Impact So far there are no tangible outputs from the collaboration, however, it is still in it's infancy.
Start Year 2019
 
Description Edinburgh Research Interest Group - Parkinson's UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact The event normally takes the form of a lecture by a prominent researcher in the field of Parkinson's, followed by coffee and tea where the patients and carers are encouraged to asks students about their research and discuss the current research landscape and what is being done to help treat their condition.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description School Visit (Castlebrae high school) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact the centre for regenerative medicine is involved in a lot with the local school and I have often helped show the students around the facility. I am also part of a group which goes to the school each week to help the pupils with exam preparation for science exams.
Year(s) Of Engagement Activity 2018,2019