Optimising Synthetic Biosynthesis of Natural Products by Yeast Genome Engineering
Lead Research Organisation:
Imperial College London
Department Name: Bioengineering
Abstract
Traditional metabolic engineering has allowed us to synthesise a host of heterologous compounds in
industrially pliable organisms for some time now. Successes include the production of human insulin
using E. coli1 or the production of the anti-malarial drug artemisinin using yeast2. However, there are
innumerable examples where a therapeutic molecule has successfully been produced in an industrial
host organism but not at commercially viable yields. This bottle-neck prevents many drugs from
being produced in potentially more sustainable and economical ways. Hence, there is increased
interest to develop novel methods to synthesise heterologous compounds at higher yields.
industrially pliable organisms for some time now. Successes include the production of human insulin
using E. coli1 or the production of the anti-malarial drug artemisinin using yeast2. However, there are
innumerable examples where a therapeutic molecule has successfully been produced in an industrial
host organism but not at commercially viable yields. This bottle-neck prevents many drugs from
being produced in potentially more sustainable and economical ways. Hence, there is increased
interest to develop novel methods to synthesise heterologous compounds at higher yields.
People |
ORCID iD |
| Glen Gowers (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/P504579/1 | 30/09/2017 | 29/09/2021 | |||
| 1982523 | Studentship | BB/P504579/1 | 01/10/2016 | 30/09/2020 | Glen Gowers |