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Neisseria meningitidis serogroup B reverse vaccinology

Lead Research Organisation: Imperial College London
Department Name: Dept of Medicine

Abstract

A new method of vaccine candidate discovery has been termed reverse vaccinology 2.0. It is based on isolating mAbs from patients who are recovering from disease, identifying their cognate antigen targets on the pathogen before investigating the potential of the antigens as vaccine candidates8. When looking for a novel protective antigen for MenB, ideal targets would be highly conserved, surface exposed and have a serum bactericidal antibody4; SBA with human complement is a surrogate of protection for meningococcal vaccines due to low incidence rates.

People

ORCID iD

Publications

10 25 50
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Bidmos FA (2018) Bacterial Vaccine Antigen Discovery in the Reverse Vaccinology 2.0 Era: Progress and Challenges. in Frontiers in immunology

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Siris S (2021) Isolating Pathogen-Specific Human Monoclonal Antibodies (hmAbs) Using Bacterial Whole Cells as Molecular Probes. in Methods in molecular biology (Clifton, N.J.)

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/R505742/1 01/11/2017 31/01/2022
2003843 Studentship BB/R505742/1 01/11/2017 23/01/2022