In Silico Design and Optimisation of Novel Host-Directed Therapies

Lead Research Organisation: Imperial College London
Department Name: Dept of Bioengineering

Abstract

Pulmonary fungal infections caused by the mould Aspergillus fumigatus range from allergic
disease to invasive infections with high associated mortality. The resultant disease phenotype is
largely due to the immune response mounted by the host in response to infection. Treatment of
these infections is challenging due to the limited antifungal options available, and increasing A.
fumigatus antifungal drug resistance. This research project will focus on the designing and
optimising immunotherapeutic regimens. The action of these immunotherapies will be exerted
through modulation of the host's immune system. Furthermore, we will investigate the role of
fungal immunotherapies as adjuvants to antifungal drug regimens to devise optimum treatment
options and reduce mortality due to A. fumigatus infection

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
NC/P00217X/1 30/09/2017 30/03/2021
2004502 Studentship NC/P00217X/1 29/09/2017 29/09/2020 Natasha Motsi