Microfluidic-based automated lab-on-a-chip cell manipulation

Lead Research Organisation: University of Birmingham
Department Name: Mechanical Engineering

Abstract

Microfluidic-based automated lab-on-a-chip cell manipulation

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509590/1 01/10/2016 30/09/2021
2007132 Studentship EP/N509590/1 01/10/2017 30/09/2020 Arran Hughes
 
Description A novel technique has been developed for the manufacture of 3D microfluidic devices utilising a femstosecond laser for the ablation of a steel mould. Additionally, this technique has been used to successfully manipulate an oocyte to maximise the chance of successful injection for the ICSI (Intracytoplasmic Sperm Injection) technique.

A device has been designed that allows for the isolation of a singular sperm from a batch for ICSI utilising current modelling techniques along with experimental validation given for parts of the model. Further to this, the entire system is being designed to validate and fully automate the isolation process utilising microfluidics.
Exploitation Route The outcomes can be used by embryologists to assist with the entire ICSI process to help provide more consistent and higher success rate procedures for consumers across all clinics.
Sectors Electronics,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Title MICROFLUIDICS SYSTEM FOR SINGLE SPERM ISOLATION 
Description The disclosure relates to methods and systems for isolating individual sperm from a semen sample using microfluidics. Example embodiments include a microfluidics system (1500) for isolating individual sperm from a semen sample, the system comprising: a first laminar flow channel (1501) extending between a first inlet (1503) and a first outlet (1505); a second laminar flow channel (1502) extending between a second inlet (1504) and a second outlet (1506); and a third laminar flow channel (1507a) extending between the first and second laminar flow channels (1501, 1502) and having a restriction (1508a) configured to prevent passage of a single sperm through the third laminar flow channel (1507a), wherein flow of a semen sample through the first laminar flow channel (1501) at a pressure higher than flow of a liquid medium through the second laminar flow channel (1502) results in a single sperm being trapped by the restriction (1508a) in the third laminar flow channel (1507a). 
IP Reference WO2019211596 
Protection Patent application published
Year Protection Granted 2019
Licensed No
Impact A joint venture has begun with St. Mary's Hospital Manchester to allow the device to be brought up in technology level such that it can be used within clinical trials.