Evolutionary responses to meiotic drive

Lead Research Organisation: University College London
Department Name: Genetics Evolution and Environment

Abstract

Meiotic drivers are selfish genetic elements that disrupt normal gamete production. We are studying sex-ratio (SR) an X-linked drive system in stalk-eyed flies. SR gains a transmission advantage through the destruction of Y-bearing sperm, but causes a deficit in the fertility of carrier males, as half their sperm are lost. You will investigate: a) whether drive cause population extinction, b) adaptive and maladaptive genomic changes in the drive chromosome, and c) develop theory to explain the frequency of meiotic drive in natural populations. The results will be used to assess "gene drive" technology for vector control.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M009513/1 01/10/2015 30/09/2023
2094173 Studentship BB/M009513/1 24/09/2018 30/09/2022 Sade Bates