Using MS Imaging (MSI) to explore T.cruzi parasite and drug distribution

Lead Research Organisation: University of Dundee
Department Name: School of Life Sciences

Abstract

Treatment of T.Cruzi, the cause of Chagas disease is extremely challenging, in part due to its complex life cycle in mammalian hosts. The parasite resides in immune privileged sites such as ovaries, testis and brain in both acute and chronic disease. Furthermore, the parasites are detected in lymph nodes in adding a further challenge to developing a chemotype to deliver the distributional requirements for cure. understanding whether lymph acts as a reservoir of just a transient pool for parasites will be critical to this end. Consequently, the ability to better detect both parasites and drugs is difficult to access tissue and different tissue regions following treatment in mouse models of infection would add significant value in our understanding of this disease and the drug distributional requirements necessary for treating this disease.

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