Cutting-edge approaches to understand how gut microbes promote our health

Lead Research Organisation: University of East Anglia
Department Name: Graduate Office

Abstract

Bifidobacteria has been highlighted as a protective agent against a number of health conditions, ranging from pathogen infection to Crohn's disease and asthma. Evidence suggests that Bifidobacteria can directly affect host processes in the gut. One such process is autophagy, a cellular degradation mechanism, known to be important for intestinal homeostasis (Nobel Prize 2016). However, we do not know the details how exactly Bifidobacteria can modulate autophagy. Studying these cross-kingdom connections will help us to understand the mechanims behind gut health benefits of commensal bacteria. To explore such a complex interplay novel approaches should be used, like systems biology, which has revolutionized our way of thinking about biological systems and allowed the identification of essential molecules at the systems-level.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011216/1 01/10/2015 30/09/2023
2116512 Studentship BB/M011216/1 01/10/2018 30/09/2022 Martina Poletti