How does the plant regulate receptor signaling to balance immune response and growth?

Lead Research Organisation: University of East Anglia
Department Name: Graduate Office


Plants sense microbial pathogens through the detection of pathogen associated molecular patterns (PAMP) and this is mediated by cell surface localised pattern recognition receptors (PRR). Perception of PAMPs triggers a signaling network that includes activation of mitogen activated protein kinases (MAPK), activation of defence gene expression and ultimately leads to PAMP triggered immunity (PTI). Perception of PAMPs also leads to growth inhibition, by mostly unknown signaling events. Since the regulation of growth also involves receptor-mediated perception of plant peptides there is potential for cross regulation. Some connections have already been identified that suggest some of the signaling components are shared between PRR signaling and plant peptide signaling, such at co-receptor BAK1 (1). Furthermore, perception of plant peptides has recently also been linked to negative regulation of defense response and suppresses resistance to microbial pathogens (2,3). The current project investigates the links between PRR signaling and plant peptide signaling controlling growth. In the current project the receptor based signaling event will be studied with advanced proteomics approaches and cell biology (using confocal microscopy). The project will also involve molecular biology and protein biochemistry allowing for a broad training of the candidate.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M011216/1 01/10/2015 30/09/2023
2116959 Studentship BB/M011216/1 01/10/2018 30/09/2019 Luke Sherwin