Mechanisms underlying the interaction of novel inflammatory mediators with sensory neurons
Lead Research Organisation:
University of Cambridge
Department Name: Pharmacology
Abstract
Using genetic, imaging and electrophysiological techniques to ascertain the populations of neurons with which novel/under-investigated inflammatory mediators interact, and the mechanisms underpinning these interactions.
People |
ORCID iD |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011194/1 | 30/09/2015 | 31/03/2024 | |||
| 2120052 | Studentship | BB/M011194/1 | 30/09/2018 | 29/09/2022 |
| Description | We have identified an interaction between a protein which is implicated in inflammatory bowel disease and pain-sensing nerves, suggesting this protein could cause pain in such diseases. The protein - Angiotensin II - is elevated in bowel tissue from patients with Crohn's disease and ulcerative colitis. We have established the identity of the nerves with which Angiotensin II interacts and have shed some light on the mechanism underlying this interaction. |
| Exploitation Route | We hope clinical researchers could take our observations further to establish whether blocking the actions of Angiotensin II on pain-sensing nerves could be a viable pain treatment for those with inflammatory bowel disease. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |