Development of Small Molecule EPAC1 Activity Modulators

Lead Research Organisation: Heriot-Watt University
Department Name: Sch of Engineering and Physical Science

Abstract

This is a PhD Research project in chemistry. This project is part of an ongoing collaborative research effort across several groups at Heriot-Watt and other institutions. The project will involve the design and synthesis of small molecule agonists and antagonists for the cellular signaling enzyme EPAC1. Design will be carried out by generating computational models of energetically favorable docking modes of existing ligands into EPAC1 homology model crystal structures before examination of these models and identification of new target analogue structures. Synthesis will then be undertaken using a wide variety of organic synthetic chemistry techniques. Samples of new compounds will then be passed on to collaborators for evaluation of biological activity.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/R513040/1 01/10/2018 30/09/2023
2123467 Studentship EP/R513040/1 01/10/2018 31/03/2022 David Morgan