A multiscale approach to studying channel dynamics.

Lead Research Organisation: University of Cambridge
Department Name: Physics

Abstract

Pores and channels are ubiquitous in cell biology. From the nuclear pore complex to cell membrane channels, they play key roles in regulating the cell environment and maintaining function. Most pores are highly specialised, however there are many properties that are predicted to be universal, and simple physical systems which allow us to probe that universality will prove useful due to the difficulty of studying pores in the busy cell environment. The aim of this project is to further develop such experimental model systems for biological pores, with both microscale and nanoscale systems being considered to construct a more comprehensive picture of the dynamics. The microscale component will be using colloidal particles and microfluidic approaches to study particle and polymer transport processes in both sparse and dense environments. The nanoscale component is concerned with using nanopores and DNA-origami to investigate the physical properties of various model pore systems, with specific interest given to the fluctuations of such systems.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/R513180/1 01/10/2018 30/09/2023
2125597 Studentship EP/R513180/1 01/10/2018 31/03/2022 Stuart Knowles