Quantitative in vivo analysis of ligand-receptor interactions in the Wnt signalling network
Lead Research Organisation:
UNIVERSITY OF EXETER
Department Name: Biosciences
Abstract
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Publications
Dawes ML
(2020)
Studying molecular interactions in the intact organism: fluorescence correlation spectroscopy in the living zebrafish embryo.
in Histochemistry and cell biology
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M009122/1 | 30/09/2015 | 31/03/2024 | |||
| 2240970 | Studentship | BB/M009122/1 | 30/09/2019 | 31/10/2023 | Michael Dawes |
| Description | A novel method for identifying proteins on cell surface projections has been developed and optimised. This method provides a non-biased approach to a previously difficult to achieve problem. The method will provide further insight to how cells communicate to other cells across short distances using signalling proteins, specifically Wnt signalling proteins. |
| Exploitation Route | the design of this method is transferable to all signalling molecules that require handover between cells. the design is simple to implement and non-biased, therefore novel proteins found by this method can be used to direct novel therapeutic targets or generate new avenues for research. |
| Sectors | Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology Other |
| URL | https://link.springer.com/article/10.1007/s00418-020-01930-5 |
| Description | We have developed a novel tool for identifying proteins that are specific to cell-cell communication through single signalling proteins. The strength of this tool is the specificity of tagging proteins that are involved in mature signalling of the protein of interest and its ability to be used for any protein of interest to the researcher. |
| First Year Of Impact | 2019 |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |