Evaluating the potential for evolution and establishment of (AMaR) drug resistance within zoonotic schistosomiasis in sub-Saharan Africa

Lead Research Organisation: Royal Veterinary College
Department Name: Pathology and Pathogen Biology

Abstract

Schistosomiasis is a neglected tropical disease which exerts a significant burden on humans and their animals, particularly the poorest people in sub-Saharan Africa. Praziquantel (PZQ) is the only available drug against schistosomiasis making the threat of resistance a particularly pertinent and worrying issue. By combining field sampling, diagnostic assays, molecular analysis and mathematical modelling, we aim to evaluate the likely impact of test-and-treat interventions on the population dynamics of livestock schistosomiasis. These findings will inform how best to control livestock schistosomiasis-while minimizing the risk of PZQ resistance developing-and how to prevent the further spread of hybrid schistosomes.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M009513/1 01/10/2015 30/09/2023
2241824 Studentship BB/M009513/1 23/09/2019 30/09/2023 Adriana Virginia Diaz Alvardo