Potentiation and repurposing of macrolide antimicrobials against Gram-negative pathogens for clinical applications in human and veterinary medicine
Lead Research Organisation:
Royal Veterinary College
Department Name: Pathology and Pathogen Biology
Abstract
The development of improved antibacterial strategies is an important global challenge. This project aims to potentiate the activity of non-critical macrolide antibiotics to the degree that they can be used to replace the use of critical antibiotics in clinical use in human and veterinary medicine, e.g., colistin. This aim will be achieved by complexing and conjugating macrolide antibiotics with peptide mimics (peptidomimetics) and antimicrobial polymers, building on strong in vitro evidence in our laboratories. The antibacterial, immunomodulatory and microbiome effects will be tested in vitro and in vivo, and by using cell systems and porcine and/or avian models.
People |
ORCID iD |
Liam Good (Primary Supervisor) | |
Lauren Hellewell (Student) |
Publications
Hellewell L
(2022)
Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review.
in Future medicinal chemistry
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/M009513/1 | 30/09/2015 | 31/03/2024 | |||
2241934 | Studentship | BB/M009513/1 | 30/09/2019 | 29/09/2023 | Lauren Hellewell |
Description | Antimicrobial activity of peptidomimetics |
Organisation | University of Copenhagen |
Country | Denmark |
Sector | Academic/University |
PI Contribution | I am providing them with results based on their peptidomimetics, as well as future efflux pump analysis. |
Collaborator Contribution | They have provided us with the synthetic peptidomimetics. |
Impact | A publication where I am first author is underway. |
Start Year | 2020 |