Targeting cardiac myosin: a structure-based approach to design conformation-selective modulators
Lead Research Organisation:
Queen Mary University of London
Department Name: Sch of Biological and Chemical Sciences
Abstract
This project aims to generate drug-like compounds able to selectively bind specific conformations of cardiac myosin.
This will be done by first using computational techniques such as Molecular Dynamics, Molecular Docking and virtual screening to identify a range of small molecules with different predicted effects on myosin function. The candidate compounds with best affinity and selectivity will be then tested on cardiac myosin and cardiomyocytes with in vitro motility assays.
Results of this research will directly impact the development of drugs to treat cardiovascular diseases such as heart failure and inherited cardiomyopathies.
This will be done by first using computational techniques such as Molecular Dynamics, Molecular Docking and virtual screening to identify a range of small molecules with different predicted effects on myosin function. The candidate compounds with best affinity and selectivity will be then tested on cardiac myosin and cardiomyocytes with in vitro motility assays.
Results of this research will directly impact the development of drugs to treat cardiovascular diseases such as heart failure and inherited cardiomyopathies.
People |
ORCID iD |
Arianna Fornili (Primary Supervisor) | |
Fariha Akter (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/N50953X/1 | 30/09/2016 | 29/09/2021 | |||
2262248 | Studentship | EP/N50953X/1 | 30/09/2019 | 30/03/2023 | Fariha Akter |
EP/R513106/1 | 30/09/2018 | 29/09/2023 | |||
2262248 | Studentship | EP/R513106/1 | 30/09/2019 | 30/03/2023 | Fariha Akter |
Description | EBSA Bursary for a working visit to a laboratory in an EBSA country |
Amount | € 1,000 (EUR) |
Organisation | European Biophysical Societies' Association |
Sector | Charity/Non Profit |
Country | Germany |
Start | 02/2022 |
End | 04/2022 |
Description | QMUL Postgraduate Research Fund |
Amount | £2,000 (GBP) |
Organisation | Queen Mary University of London |
Sector | Academic/University |
Country | United Kingdom |
Start | 02/2022 |
End | 04/2022 |
Description | The Physiological Society Travel Grant (Members) |
Amount | £500 (GBP) |
Funding ID | 71193-FR-Fariha Akter |
Organisation | Physiological Society |
Sector | Charity/Non Profit |
Country | Global |
Start | 02/2022 |
End | 04/2022 |