A synthetic biology toolbox for electronic control of gene expression

Lead Research Organisation: Imperial College London
Department Name: Dept of Chemistry

Abstract

The 20th Century was characterized by the growth of a myriad of technologies based on digital
electronics. Engineering of biological systems has the potential to be similarly revolutionary in the
21st Century. Before this dream can be realized, however, precise, programmable control of
complex biological systems needs to become simpler, and the interface with other engineered
technologies needs to be made more robust. In this project, the student will develop a modular
system for interfacing electronic signals with engineered cells. The proposed mechanism utilizes
electrochemical oxidation and reduction of redox molecules at electrodes, and the subsequent
activation of redox-sensitive transcription factors in the vicinity of those electrodes. The
electrogenetic module will allow implementation of precise spatio-temporal control of biological
systems from a smartphone or personal computer, with applications in bioproduction, biomaterials,
biosensors, diagnostics and more.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S023518/1 01/10/2019 31/03/2028
2279868 Studentship EP/S023518/1 01/10/2019 31/12/2022 Alicia Climent Catala