Cell Signalling in Tumor Growth and Tissue Mechanics

Lead Research Organisation: University of Nottingham
Department Name: Sch of Mathematical Sciences

Abstract

Cells respond to their physical environment through mechanotransduction, the translation of mechanical forces into biochemical signals; evoked cell phenotypic changes can lead to an altered cell microenvironment, creating a developmental feedback. Interplay between such mechanosensitive pathways and other inter- and intra-cellular signalling mechanisms determines cell differentiation and, ultimately, tissue development. Such developmental mechanisms have key relevance to the initiation and development of cancer, a disease of such inherent complexity (involving the interaction of a variety of processes across disparate spatio-temporal scales, from intracellular signalling cascades to tissue-level mechanics) that, despite a wealth of theoretical and experimental studies, it remains a leading cause of mortality and morbidity: in the UK, more than one in three people will develop some form of cancer. There is therefore an urgent need to gain greater quantitative understanding of these highly complex systems, which are well-suited to mathematical study

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/R513283/1 01/10/2018 30/09/2023
2280896 Studentship EP/R513283/1 01/10/2019 31/03/2023 Jacob Jepson