Characterization of human neurons expressing the glucagon-like peptide 1-receptor (GLP1-R)
Lead Research Organisation:
UNIVERSITY OF CAMBRIDGE
Department Name: Institute of Metabolic Science
Abstract
Rotation 1 - October - December 2019
Characterization of human neurons expressing the glucagon-like peptide 1-receptor (GLP1-R)
Characterization of human neurons expressing the glucagon-like peptide 1-receptor (GLP1-R)
Publications
Dowsett G
(2023)
Mapping the Feeding Circuitry in the Mouse and Human Brain
Dowsett GKC
(2021)
A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.
in Molecular metabolism
Gupta D
(2021)
High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets.
in Endocrinology
Lam B
(2021)
MC3R links nutritional state to childhood growth and the timing of puberty
in Nature
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011194/1 | 30/09/2015 | 31/03/2024 | |||
| 2292908 | Studentship | BB/M011194/1 | 30/09/2019 | 29/09/2023 | Georgina Dowsett |
| Description | We identified key cell populations in the mouse hindbrain and their potential roles in food intake control. We made this resource available which will help delineate the mechanisms underlying the effectiveness of current therapeutics for the treatment of obesity. |
| Exploitation Route | We made this resource available which will help delineate the mechanisms underlying the effectiveness of current therapeutics for the treatment of obesity and be useful in identifying new therapeutic targets. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Study on GHSR expression in pancreatic islet cells |
| Organisation | University of Texas Southwestern Medical Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Data analysis for publication |
| Collaborator Contribution | Wrote a publication together (PMID: 34289060) |
| Impact | Publication PMID 34289060 |
| Start Year | 2020 |