Modelling supercoiling and epigenetics in DNA and chromatin

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Physics and Astronomy


The project will cover different aspects of the physics of DNA. Our aim, in the first part of the project, will be to spotlight how supercoiling can influence transcription and then how it can regulate gene expression. Indeed several experiments suggest that DNA supercoiling and transcription are intimately connected each other. In the second part, we will build on existing models and codes which describe DNA at various length scales or levels of coarse graining in order to study how DNA folds up in the 3-dimensional space inside a living cell. In the final part of the project, we will study the spreading dynamics of epigenetic marks in chromatin.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509644/1 01/10/2016 30/09/2021
2308202 Studentship EP/N509644/1 01/12/2016 31/10/2020 Alessandro Bentivoglio