New insights into catalysis with film electrochemical EPR - from small molecules to complex proteins
Lead Research Organisation:
Imperial College London
Department Name: Chemistry
Abstract
Radical intermediates often play an important role in the catalytic reactions of redox-active proteins. Yet, catching these intermediates and analyzing them in detail to gain insight into the mechanism of catalysis can pose a significant challenge. In this project, we extend a novel technique, film electrochemical electron paramagnetic resonance spectroscopy (FE-EPR), to enable the investigation of small molecules and proteins undergoing catalysis. In particular, respiratory complex I will be studied under catalysis with FE-EPR, to provide experimental insight into the elusive redox-proton pump coupling in this giant enzyme essential for ATP synthesis.
Organisations
People |
ORCID iD |
Maxie Roessler (Primary Supervisor) | |
Adam Sills (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/R513052/1 | 01/10/2018 | 30/09/2023 | |||
2376400 | Studentship | EP/R513052/1 | 01/06/2020 | 30/06/2023 | Adam Sills |