Radio-labelled responsive fluorophores to elucidate the role of MMP in ageing
Lead Research Organisation:
University College London
Department Name: Chemistry
Abstract
Matrix metalloproteinases (MMPs) play an essential role in a variety of biological processes,
including ageing. Within this project, a new platform of multifunctional probes for the detailed
study of MMP's role in age-related diseases will be developed. The probes will consist of an
organic fluorophore covalently linked to a PET-tracer and anchored via an MMP cleavable
peptide sequence to a black-hole quencher (BHQ). The PET-tracer will allow for the spatial
monitoring of the probe's diffusion in the cellular matrix, while the BHQ will add temporal
resolution when cleaved by MMP, thereby "turning-on" the fluorescence.
including ageing. Within this project, a new platform of multifunctional probes for the detailed
study of MMP's role in age-related diseases will be developed. The probes will consist of an
organic fluorophore covalently linked to a PET-tracer and anchored via an MMP cleavable
peptide sequence to a black-hole quencher (BHQ). The PET-tracer will allow for the spatial
monitoring of the probe's diffusion in the cellular matrix, while the BHQ will add temporal
resolution when cleaved by MMP, thereby "turning-on" the fluorescence.
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/T008709/1 | 01/10/2020 | 30/09/2028 | |||
| 2396719 | Studentship | BB/T008709/1 | 01/10/2020 | 30/12/2024 | Ana-Maria Ivanus |