The Development of Drug-eluting Electrospun Devices for Clinical Applications in Gynaecology

Lead Research Organisation: University of Sheffield
Department Name: Materials Science and Engineering

Abstract

Gynaecological conditions may be painful and frequently impact negatively on a woman's quality of life with a range of symptoms that include abnormal bleeding or discharges, difficulty in passing urine, and/or reduced fertility. Current treatments have limitations in many cases, for example systemic drugs require a relatively high dose that risks side effects, while local topical creams may be rapidly washed away. Pessaries have been effective for some forms of drug delivery, but are not applicable for all conditions and have known drawbacks.

The multidisciplinary team supervising this project have a successfully developed an innovative electrospun polymer devices for delivery of therapeutic agents as a platform technology, and this has already been applied to address unmet clinical needs in oral medicine. This platform technology is however applicable to a wider range of situations where local drug delivery is challenging, and we propose here to extend to the field of gynaecology. Gynaecological conditions that would benefit from direct and sustained drug delivery include infections (eg Candida albicans) and lichenoid reactions in the vagina, endometriosis in the uterus, and promotion of healing post-surgery.

The aim of this research is therefore to design, fabricate, characterise and evaluate electrospun patches for unmet needs in gynaecology. On completion, by working with our clinical collaborators and industrial partners (Afyx Therapeutics in Copenhagen), th

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S022201/1 01/04/2019 30/09/2027
2432154 Studentship EP/S022201/1 01/10/2020 30/09/2024 Kathryn Margaret Dickins