The role of extracellular matrix in cortical malformations of the developing human brain.
Lead Research Organisation:
King's College London
Department Name: Developmental Neurobiology
Abstract
The aim of this PhD project is to elucidate the role of the extracellular matrix in cortical malformations and injury in the developing human brain.
Aim 1: Proteomic analysis of the ECM present in the human fetal brain.
The samples required for this have already been collected. This work will be supported by collaboration with Prof. Patrizia Ferretti, Institute of Child Health, UCL.
Aim 2: Identify ECM present in critical periods of human cortex development for cortical malformations.
This will be based on the proteomic analysis in Aim 1, but also using evidence from the literature. Candidate ECM components will be selected for Aim 3 based on their known function and expression patterns.
Aim 3: Investigate the role of the candidate ECM components in cortical development, injury and malformations using human fetal explant cultures.
Aim 1: Proteomic analysis of the ECM present in the human fetal brain.
The samples required for this have already been collected. This work will be supported by collaboration with Prof. Patrizia Ferretti, Institute of Child Health, UCL.
Aim 2: Identify ECM present in critical periods of human cortex development for cortical malformations.
This will be based on the proteomic analysis in Aim 1, but also using evidence from the literature. Candidate ECM components will be selected for Aim 3 based on their known function and expression patterns.
Aim 3: Investigate the role of the candidate ECM components in cortical development, injury and malformations using human fetal explant cultures.
People |
ORCID iD |
| Jonathan O'Muircheartaigh (Primary Supervisor) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/P502108/1 | 01/10/2017 | 30/09/2024 | |||
| 2433255 | Studentship | MR/P502108/1 | 01/10/2020 | 30/09/2024 |