New imaging methodologies for receptor-targeted therapies

Lead Research Organisation: King's College London
Department Name: Imaging & Biomedical Engineering

Abstract

Aim of the PhD Project:

Develop new bioconjugate and chelator chemistry to incorporate metallic ions into antibodies.
Study the distribution of the new chelator-antibody conjugates tagged with non-radioactive metals in vivo (tumour-bearing mice) using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS).
Radiolabel the new chelator-antibody conjugates with therapeutic radiometallic ions and undertake radiotherapeutic efficacy studies in cancer models.



The overarching objective of this project is to develop new chemical technology to attach heavy metal tags to antibodies, and apply this technology to quantify/image the biodistribution of radioactive and non-radioactive antibody-based therapies in vivo in mouse models using radionuclide imaging methods. This will enable high resolution, sensitive and quantitative mapping of such therapies, and give insight into their therapeutic efficacy.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S022104/1 01/10/2019 31/03/2028
2440765 Studentship EP/S022104/1 01/10/2020 30/09/2024 Natasha Patel