SSA: Investigating how imprinted Grb10 influences brain growth

Lead Research Organisation: Cardiff University


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/T008741/1 30/09/2020 29/09/2028
2441134 Studentship BB/T008741/1 30/09/2020 29/09/2024
Description I have conducted longitudinal volumetric MRI analysis and shown that there is a significant difference in whole brain volume between adult mice with and adult mice without paternal Grb10 expression. This indicates Grb10 impacts proliferation, specifically neurogenesis as Grb10 is expressed in neurons, which is being investigated currently. Understanding the impact of Grb10 and its implications involving adult neurogenesis could have applications to neurodegenerative diseases.
Exploitation Route It will primarily be a foundation to inform the direction of future research and the project's research will be built on to understand the mechanism of Grb10 on brain growth and the wider implications.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology