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Investigating the role of TRP channels in the pathogenesis of multiple sclerosis

Abstract

Research Question: Does oligodendrocyte TRPA1 channel regulate glial functioning and lead to less demyelination and increased remyelination in conditional TRPA1 -/-in oligodendrocytes compared to global TRPA1 -/-mice?

Hypothesis:TRPA1 channels expressed on oligodendrocyte regulate glial functioning and become dysfunctional during demyelinating disease; TRPA1 -/-in oligodendrocytes is protective against demyelinationin the rodent cuprizone model.

Aim 1:Validate the conditional TRPA1 -/-in oligodendrocyte compared to global TRPA1 -/-mice.

Aim 2:Through use of the cuprizone model, determine the extent of demyelination in conditional TRPA1 -/-vs WT

Aim 3:Through use of the cuprizone model, determine the extent of remyelination in conditional TRPA1 -/-vs WT

People

ORCID iD
Grace Flower (Student)

Publications

10 25 50
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Flower G (2022) Editorial: Journey to the Center of the Brain: Cell Physiology and Intercellular Communication in White Matter. in Frontiers in cellular neuroscience

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Lajoso W (2021) Transient Receptor Potential Ankyrin-1 (TRPA1) Block Protects against Loss of White Matter Function during Ischaemia in the Mouse Optic Nerve. in Pharmaceuticals (Basel, Switzerland)

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/N013700/1 30/09/2016 29/09/2025
2444359 Studentship MR/N013700/1 30/09/2020 29/06/2024 Grace Flower