Investigating the role of TRP channels in the pathogenesis of multiple sclerosis
Lead Research Organisation:
King's College London
Department Name: Wolfson Centre for Age Related Diseases
Abstract
Research Question: Does oligodendrocyte TRPA1 channel regulate glial functioning and lead to less demyelination and increased remyelination in conditional TRPA1 -/-in oligodendrocytes compared to global TRPA1 -/-mice?
Hypothesis:TRPA1 channels expressed on oligodendrocyte regulate glial functioning and become dysfunctional during demyelinating disease; TRPA1 -/-in oligodendrocytes is protective against demyelinationin the rodent cuprizone model.
Aim 1:Validate the conditional TRPA1 -/-in oligodendrocyte compared to global TRPA1 -/-mice.
Aim 2:Through use of the cuprizone model, determine the extent of demyelination in conditional TRPA1 -/-vs WT
Aim 3:Through use of the cuprizone model, determine the extent of remyelination in conditional TRPA1 -/-vs WT
Hypothesis:TRPA1 channels expressed on oligodendrocyte regulate glial functioning and become dysfunctional during demyelinating disease; TRPA1 -/-in oligodendrocytes is protective against demyelinationin the rodent cuprizone model.
Aim 1:Validate the conditional TRPA1 -/-in oligodendrocyte compared to global TRPA1 -/-mice.
Aim 2:Through use of the cuprizone model, determine the extent of demyelination in conditional TRPA1 -/-vs WT
Aim 3:Through use of the cuprizone model, determine the extent of remyelination in conditional TRPA1 -/-vs WT
Organisations
People |
ORCID iD |
| Nicola Hamilton-Whitaker (Primary Supervisor) | |
| Grace Flower (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013700/1 | 01/10/2016 | 30/09/2025 | |||
| 2444359 | Studentship | MR/N013700/1 | 01/10/2020 | 31/03/2024 | Grace Flower |