Investigating CD1c Lipid-antigen presentation and its role in tuberculosis
Lead Research Organisation:
University of Southampton
Department Name: Clinical and Experimental Sciences
Abstract
The project studies the host-pathogen interaction in human tuberculosis and investigates the role of unconventional CD1-restricted T cells in the control of infection. The molecular basis of how lipid/CD1c regulates TCR recognition, and the functional role of CD1c-restricted T cells in human TB remain unknown.
It is hypothesised that CD1c and its restricted T cells regulate the host-pathogen interaction in human TB. This study aims to define the molecular mechanisms underpinning T cell recognition of CD1c, and in particular to investigate the functional effect of these T cells in TB.
It is hypothesised that CD1c and its restricted T cells regulate the host-pathogen interaction in human TB. This study aims to define the molecular mechanisms underpinning T cell recognition of CD1c, and in particular to investigate the functional effect of these T cells in TB.
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N014308/1 | 01/10/2016 | 30/09/2025 | |||
| 2450017 | Studentship | MR/N014308/1 | 07/01/2019 | 30/09/2022 | Sahar Farag |
| MR/R502261/1 | 01/10/2017 | 30/09/2022 | |||
| 2450017 | Studentship | MR/R502261/1 | 07/01/2019 | 30/09/2022 | Sahar Farag |
| MR/R015686/1 | 01/10/2018 | 30/09/2025 | |||
| 2450017 | Studentship | MR/R015686/1 | 07/01/2019 | 30/09/2022 | Sahar Farag |