Multivalent display of antigens via site selective enzymatic modification

Lead Research Organisation: University of Leeds
Department Name: Sch of Chemistry


A major question in vaccine development is the significance of heterogeneity in conjugate vaccine development. In this project, the student will develop a variety of chemoenzymatic strategies to synthesize homogenous site-specifically labelled multimeric proteins with defined labelling stoichiometry. These will then be adapted for application to conjugate model antigens. The effect of site-specific conjugation in defined stoichiometry to random labelling will then be evaluated.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/V50953X/1 01/10/2020 30/09/2024
2464671 Studentship BB/V50953X/1 01/10/2020 30/09/2024 Alexandra Tamasanu