Carbonyl Alkylative Amination as a Tool for the Array Synthesis of Complex Amines

Lead Research Organisation: University of Cambridge
Department Name: Chemistry

Abstract

Year 1: Generic training activities for all first-year student members of the CDT.

Year 2-4: Microscale array synthesis allows for the systematic interrogation of chemical interactions with minimal material use. The zinc-mediated carbonyl alkylative amination reaction's multicomponent nature and generality makes it ideal for generating diverse libraries of complex amines. We will develop a platform for the high throughput-enabled generation of microscale complex amine arrays. Microscale reaction conditions and product generation have been confirmed but issues with reactive species prevent simple LCMS analysis. Instead, parallel scavenger-resin based purification allows for reaction outcome analysis by NMR. A new workflow based on immediate reaction purification coupled with high throughput NMR is proposed, with the CAA reactivity on microscale confirmed. However, a reaction material mass loss issue currently prevents further optimisation and development.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S024220/1 31/05/2019 30/11/2027
2468412 Studentship EP/S024220/1 30/09/2020 29/09/2024 Joseph Phelps