Amplified Self-Immolative Elimination of AMP-Drug Conjugates

Lead Research Organisation: University of Cambridge
Department Name: Chemistry

Abstract

Year 1: Generic training activities for all first-year student members of the CDT.

Year 2-4: There is growing need for effective antimicrobial agents to fight against the antimicrobial resistance crisis. Many known antibiotics fail to be effective against Gram-negative bacteria due to poor membrane permeability, inducing the need for large doses that lead to toxicity and so fail as therapeutics. Antimicrobial peptides (AMPs) are a naturally-occurring class of antibiotics. They are found in all forms of life and are adept at membrane penetration. Conjugation of AMPs with antibiotics allow for an effective therapy while decreasing the chance of resistance forming. Conjugates with self-immolative linkers enable the release of the constituent therapeutics in the presence of a specific chemical trigger, thus increasing the selectivity for the target. Additionally, an amplified self-disassembling system can be used for multiple drug molecule release, increasing the potency of the conjugate.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S024220/1 31/05/2019 30/11/2027
2468554 Studentship EP/S024220/1 30/09/2020 29/09/2024 Thomas Wharton