Combining cutting edge molecular microbiology and super-resolution microscopy to reveal how bacteria divide, and how to stop them

Lead Research Organisation: Newcastle University
Department Name: Biosciences Institute

Abstract

During this PhD we will use super-resolution microscopy to reveal how the septum is built, and how antimicrobials physically compromise septum integrity. This strongly AMR-relevant discovery science project aims to reveal critical, potentially druggable, weak links in bacterial division. This work will be performed in the primary Gram-positive model organism Bacillus subtilis. Due to the highly conserved nature of cell division proteins, insight gained here is directly relevant to pathogens such as MRSA and Streptococcus pneumoniae.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/N013840/1 01/10/2016 30/09/2025
2469621 Studentship MR/N013840/1 01/10/2020 12/03/2025 Mia Conduit