Point-of-Care Electrochemical Biosensor for Nervous System Applications

Lead Research Organisation: University of Cambridge
Department Name: Chemical Engineering and Biotechnology

Abstract

This project proposes the development of a point-of-care biosensor which would detect the presence of biomarkers in the blood that are indicative of disease or dysfunction of the central or peripheral nervous system with high specificity and accuracy. Important biomarkers are continuously being identified and validated which can complement or replace typical diagnostic methods to confirm the presence of a disease. Examples include S100B, FAP and NSE which are present in the blood shortly after traumatic brain injury (O'Connell et al. 2018). Equally, inflammatory and anti-inflammatory markers may be important to understanding the interplay between the gut and the brain - the enteric nervous system. Complementary recognition elements need to be identified along with a suitable method for conjugation to the electrode - a skillset which would be developed in the Midi project. This project will involve the fabrication of an organic electrochemical transistor (OECT) where the doping level modulation occurs in the bulk of the conductive polymer film, resulting in especially high currents for very small gate fluctuations. When coupled with biorecognition elements, this inherent amplification results in highly sensitive transduction of biological events including the enzymatic and electrochemical detection of biomolecules (Pappa et al. 2018). There are a wide range of potential applications for which OECTs can be used to detect molecules of interest and the expertise of the two participating research groups can be drawn on the guide a specific sensor to meet clinical need.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S022953/1 30/09/2019 30/03/2028
2482382 Studentship EP/S022953/1 30/09/2020 29/09/2024 Reece McCoy