Evolving cyclopropane fatty acid synthase (CFAS) enzymes into biocatalysts for the synthesis of cyclopropane containing drugs and chemicals

Lead Research Organisation: University College London
Department Name: Chemistry

Abstract

This project is a new collaboration between GSK and Dr Daniele Castagnolo (DC) at King's College London and is aimed at the characterization and engineering of cyclopropane fatty acid synthase (CFAS) enzymes to turn them into biocatalysts for the synthesis of cyclopropane containing drugs and chemicals through more sustainable industrial processes. The project fully aligns with the BBSRC strategic priority "New strategic approaches to industrial biotechnology".

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/W510178/1 01/10/2021 28/02/2022
2606421 Studentship BB/W510178/1 01/10/2021 30/09/2025 Blazej Czemerys