Evaluate and design anti-viral actives

Lead Research Organisation: University of Birmingham
Department Name: Chemical Engineering

Abstract

Viruses present in a broad range of shapes and sizes, but are much smaller than bacteria. The notorious ones, including influenza, rotavirus, norovirus, respiratory syncytial virus, and of course coronavirus, are enveloped by lipid membrane, which could be disrupted by amphiphilic actives, in either bulk liquid or at solid/liquid interface. The chemical industry needs to work with virologists in addressing critical questions such as, which actives should be used? What are the action mechanisms? At what concentration? Under which conditions? We aim to develop effective anti-viral compounds that can intervene and inactivate viruses at various stages of transmission.
Several levers have been identified to inhibit virus transmission. From anti-viral compounds point of view, it requires a coherent programme linking molecular architecture design to lab validation, using colloidal science, formulation engineering, and viral testing capability.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S023070/1 30/09/2019 30/03/2028
2609866 Studentship EP/S023070/1 30/10/2021 31/10/2025 Daniele Remoli