The comorbidity of obsessive-compulsive disorder and schizophrenia: the interplay between psychosocial and genetic risk.

Lead Research Organisation: King's College London
Department Name: Psychology


Obsessive-compulsive disorder (OCD) and schizophrenia
(SCZ) are highly comorbid; however, the mechanisms
underlying this comorbidity are not well researched. Using
data from Avon Longitudinal Study of Parents and Children
(ALSPAC) longitudinal cohort study and the UK Biobank, I
will 1) investigate symptom level associations between
OCD and SCZ using network modelling and identify the
bridge symptoms that can help explain the co-occurrence
of these two disorders; 2) identify common and unique
psychosocial risk factors underlying OCD and SCZ; 3)
examine polygenic risk scores to assess gene-environment
interplay underlying the comorbidity between OCD and


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
ES/P000703/1 30/09/2017 29/09/2027
2613455 Studentship ES/P000703/1 30/09/2021 29/09/2025 Engin Keser